Fluorescence of 2, 4, 6, 8-Substituted Pyrimido-[5, 4d]-pyrimidines

Synthesis, antiviral, antituberculostic and antibacterial activities of some novel, 4-(4'-substituted phenyl)-6-(4"-hydroxyphenyl)-2-(substituted imino) pyrimidines.

A variety of novel 4-[(4'-substituted phenyl)-6-(4"-hydroxyphenyl)-2-substituted imino] pyrimidines were synthesized by reacting 4-(4'-substituted phenyl)-6-(4"-hydroxyphenyl)-2-aminopyrimidines with different substituted aromatic aldehydes, with coumarin and with chloroisatin. The 4-(4'-chlorophenyl)-6-(4"-hydroxyphenyl)-2-aminopyrimidines were synthesized by reacting 3-(4'-substituted phenyl)...

Enzyme induction in nutritional mutants in presence of 5-amino-2, 4-bis(substituted-amino)pyrimidines.

Enzyme induction was determined by measuring the formation of f3-galactosidase in E. coli. Unless otherwise stated, the materials and methods were the same as given previously (Kunkee, 1960a). Nutritional mutants of E. coli. We are grateful to Professor A. B. Pardee, University of California (Berkeley), for providing the pyrimidinerequiring mutant (6386) of E. coli (isolated by Professor B. D. ...

Stimulation of enzyme induction by 5-amino-2, 4-bis(substituted-amino)pyrimidines.

Several investigators (Creaser, 1955; Pardee, 1955; Spiegelman et al., 1955; Horowitz et al., 1958) have shown inhibition of enzyme induction by pyrimidine and purine analogues. The inhibition results apparently from interference with nucleic acid synthesis. In experiments with other compounds which might interfere with nucleic acid metabolism, we found a stimulation of enzyme induction in Esch...

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